Bipolar disorder
Conditions
Interventions
Case group:NO
Sponsors
General Hospital of Ningxia Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 29 Years
Inclusion criteria
Inclusion criteria: 1. Meet the DSM-V diagnostic criteria, which require the patient to have experienced at least one hypomanic episode and one moderate or severe depressive episode during the course of the illness, but no manic episodes (diagnosed as first-episode bipolar disorder type II by two or more attending physicians based on clear and independent criteria);2.Aged between 18-29, as BD-II has an early onset, and to avoid changes in estrogen levels in postmenopausal women, focusing on puberty development, where metabolic rate increases the fastest, reaching a peak at the age of 30;3. Score based on the patient's most recent depressive episode;4. The duration of the disease does not exceed 5 years;5. Currently, no psychotropic drugs are being used;6. For female subjects with fertility, the urine pregnancy test must be negative during screening;7. The patient and/or legal guardian signs the informed consent form. Control group:1. Never diagnosed with any neuropsychiatric disorder;2. Aged 18-29, their age and gender matched with the bipolar II disorder group, and recruited from the Mental Health Center of the Affiliated Hospital of Ningxia Medical University;3. No history of major physical illness or genetic disorders;4. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1.The presence of any concurrent severe medical conditions, including physical diseases, endocrine diseases, heart diseases, immune system-related diseases, etc;2. There is comorbid neuropsychiatric disorder that meets the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders-V (DSM-V), such as intellectual disability, dementia, and other mental illnesses;3. Acute or chronic infection within the past month;4. Medications that affect blood electrolyte, hormone, and lipid metabolism have been used within 2 weeks;5. Those who have participated in strenuous exercise within one week;6. Individuals who abuse alcohol or drugs;7. Taking antipsychotic drugs within 1 month before enrollment;8. Those who have received electroconvulsive therapy or cranial brain stimulation therapy within 6 months before enrollment;9. Severe abnormalities in liver and kidney function;10. Those who are currently receiving treatment with hypoglycemic, antihypertensive, lipid-lowering, and medications that affect uric acid levels;11. Severe cardiovascular disease;12. Women who are breastfeeding or pregnant;13. Patients with hematological diseases;14. Refuse to participate. Control group: 1. Individuals with severe physical illnesses or those who have undergone surgery recently; 2. Patients with organic brain diseases or dementia; 3. Pregnant or breastfeeding women; 4. Other exclusion criteria same as those for the case group mentioned above; 5. Individuals with a history of substance abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum calcium;Serum phosphorus;Calcium-regulating hormone;Blood lipid; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale;Hamilton Anxiety Scale;Young Mania Rating Scale;WHO Quality of Life-100;Social Disability Screening Schedule;Self-Esteem Scale;Defense Style Questionnaire;UCLA Loneliness Scae,University of California at Los Angels;Bech-Rafaelsen Mania Rating Scale;Ottawa Self-injury Inventory; | — |
Countries
China
Contacts
Public ContactChen Yanhua
General Hospital of Ningxia Medical University
Outcome results
None listed