Quantitative Iris Blood Flow Analysis via OCTA for Evaluating Extraocular Muscle Disease Activity in Thyroid Eye Disease

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2500112267

Enrollment

Unknown

Registered

2025-11-12

Start date

2026-01-01

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thyroid eye disease

Interventions

Inflammatory Group:none

Non-inflammatory Group:none

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Aged >= 18 years, with TED diagnosed per Bartley criteria; 2. No history of corticosteroid pulse therapy, immunosuppressive/biological agents, or orbital decompression surgery in the past 3 months; 3. No prior ocular radiation therapy; 4. Clinical Activity Score (CAS) < 3 points.

Exclusion criteria

Exclusion criteria: 1. TED with dominant compressive optic neuropathy; 2. Other intraocular diseases (uveitis, diabetic retinopathy, glaucoma) or prior intraocular surgery; 3. Corneal opacities interfering with iris imaging (e.g., corneal clouding, arcus senilis, scars, pterygium); 4. Poorly controlled hypertension/diabetes (known to affect intraocular blood flow).

Design outcomes

Primary

Measure	Time frame
Iris vascular density, IVD;orbital MRI;	—

Secondary

Measure	Time frame
Corneal limbal vascular network;	—

Countries

China

Contacts

Public ContactFang Wei

Eye Hospital, Wenzhou Medical University

andyfang000@163.com+86 571 8607 2073

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026