None
Conditions
Interventions
Observation group:None
Sponsors
Zhongshan People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Voluntary signing of the informed consent form; 2. Age >= 18; 3. Expected mechanical ventilation duration >= 24 hours; 4. Patients with consciousness disorders (GCS <= 12 or RASS <= -3).
Exclusion criteria
Exclusion criteria: 1. Surgical patients 2. Peripheral vascular disease (upper extremity atherosclerosis, Raynaud's phenomenon, thromboangiitis obliterans, previous upper extremity vascular trauma or surgery, or wrist-brachial index WBI1.3) 3. Spinal cord injury 4. Brainstem/thalamic stroke 5. Severe peripheral neuropathy and disease 6. Brachial plexus injury 7. Guillain-barre syndrome 8. Use neuromuscular blocking agents 9. Multiple sclerosis, amyotrophic lateral sclerosis 10. Severe liver failure (Child-Pugh class C) 11. Severe arrhythmias (atrial fibrillation, frequent premature ventricular contractions) 12. Severe edema of the upper limbs 13. Core temperature 39 ° C 14. Burn or trauma precludes finger PPI monitoring 15. Fingertip capillary filling time >=3s 16. Near death 17. Use of high doses of vasoactive drugs (one of these: norepinephrine >=0.3µg/kg/min or equivalent, dopamine >=15µg/kg/min or epinephrine >=0.1µg/kg/min, vasoactive drug index (VIS) >=30); 18. Bispectral index (BIS) < 20, or with any one of the "supraorbital notch press/sternal press" standardized stimulus responsiveness screens were excluded: Patients with no behavioral response (?CPOT=0) or no physiological response (?HR<5 or ?MAP<5 MMHG) to noxious stimuli, or no neurophysiological response (?BIS <5); 19. According to the investigator's judgment, he was not suitable to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ?PPI%;?COPT;Analysis of the Specific Response Pattern of PPI to Noxious Stimuli;Correlation analysis of ?PPI% with ?CPOT and ?BIS; | — |
Secondary
| Measure | Time frame |
|---|---|
| ?HR??ABP??BIS;Comparison of pain recognition performance with different parameters;Analysis of the stratified effect of consciousness level on the predictive efficacy of PPI; | — |
Countries
China
Contacts
Public ContactLizhen Zhu
Zhongshan People’s Hospital(Affiliated Zhongshan Hospital of Sun Yat-sen University)
Outcome results
None listed