Adolescent Major Depressive Disorder
Conditions
Interventions
Real intervention Group:a-iTBS
Sham Stimulation Group:Sham a-iTBS intervention
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1.Aged between 12 and 18 years, regardless of gender. 2.Han Chinese ethnicity. 3.Right-handed. 4.Meet the DSM-5 diagnostic criteria for a major depressive episode, as confirmed by two psychiatrists using the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL) structured interview. 5.A score of >=17 on the 17-item Hamilton Depression Rating Scale (HAMD-17). 6.No change in the type or dosage of any psychotropic medications in the past 4 weeks, and no history of physical therapy (e.g., rTMS, ECT) in the past 6 months. 7.Possess the capacity to provide informed consent and complete the scale assessments. 8.For participants under 18 years of age, written informed consent must be provided by both the participant themselves and their legal guardian.
Exclusion criteria
Exclusion criteria: 1.Meet the diagnostic criteria for any other DSM-5 psychiatric disorder (comorbid with depression). 2.Presence of severe suicidal ideation or a history of suicidal behavior. 3.Comorbid with major organic brain disorders or significant physical illnesses (e.g., endocrine, immune, infectious diseases, or major trauma). 4.A personal history of seizures or a family history of epilepsy. 5.A history of alcohol or substance dependence. 6.A history of head injury or coma. 7.Any contraindications for TMS or MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scores on RRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Indicators related to adverse events;Functional indicators of brain networks related to resting-state magnetic resonance;Assessment of depression, anxiety symptoms; | — |
Countries
China
Contacts
Public ContactXiaoli Liu
Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed