Methamphetamine use disorder
Conditions
Interventions
Control group:None
Sponsors
Jiangsu Province Official Hospital
Eligibility
Sex/Gender
Male
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1.Eligibility criteria for participants in the health study: Healthy adult men and non-lactating women who are not pregnant, aged between 20 and 50 years old, with men weighing at least 50kg and women weighing at least 45kg. (2) Good health, with no history of liver, kidney, digestive tract, nervous system, mental disorders or metabolic diseases; There is no history of other chronic diseases. (3) Before the trial, sign the informed consent form, fully understand the content, process and possible adverse reactions of the trial, and be able to communicate well with the researcher. 2. Eligibility criteria for participants in the methamphetamine addiction study: Participants who inhaled methamphetamine with a net content of 100mg to 120mg within 7 days (ensuring the validity of the sample), aged between 20 and 50 years old, with a male weight of at least 50kg and a female weight of at least 45kg. (2) Be diagnosed in relevant drug rehabilitation units as meeting the substance addiction diagnostic criteria in DSM-V (Diagnostic and Statistical Manual of Mental Disorders: Substance Related and Addiction Disorders), and complete the compliance physical examination at the same time. Has detailed medical records, and has a history of heart, liver, kidney, digestive tract, nervous system, mental abnormalities and metabolic diseases. There is no history of other chronic diseases. (3) Before the trial, sign the informed consent form, fully understand the content, process and possible adverse reactions of the trial, and be able to communicate well with the researcher.
Exclusion criteria
Exclusion criteria: 1. Surgery is planned within approximately six months in the near future. 2. People with a specific history of allergies (such as asthma, measles, eczema, etc.), or those with allergic constitutions (such as those allergic to two or more drugs, foods, and pollen); 3. Those who have plans to have children in the near future (within 6 months) and are unwilling to accept contraceptive measures during the study period; 4. Participants in the health study have a history of psychotropic substance abuse; Participants in the methamphetamine addiction study had a history of abuse of psychotropic drugs other than methamphetamine. 5. Positive for human immunodeficiency virus antibody (HIV-Ab), hepatitis B surface antigen (HBsAg), hepatitis C virus antibody (HCV-Ab), or Treponema pallidum antibody (RPR); 6. Previous experience of fainting at the sight of blood or needles, or difficulty in blood collection; 7. Research participants may be unable to complete this study for other reasons or may be deemed unsuitable to participate in this study by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Circular RNA;Craving Assessment Scale score;Lactic acid; | — |
Countries
China
Contacts
Public ContactBo Gui
Jiangsu Province Official Hospital
Outcome results
None listed