Thyroid nodules
Conditions
Interventions
BRAF V600E-positive group:None
Sponsors
Renji Hospital, School of Medicine in Shanghai Jiao Tong University, Shanghai
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.The initial ultrasound examination showed at least one thyroid nodule, and fine-needle aspiration was performed in the hospital. There were cytological test results and molecular test results, and the preoperative BRAF V600E test result was positive 2. After assessment by a surgeon, there are surgical indications. The surgical indications include but are not limited to one of the following situations: 1) Thyroid nodules may compress or affect appearance; 2) The patient subjectively requests surgical removal of the nodule; 3) Fine needle aspiration biopsy (FNAB) does not determine the benign or malignant nature of the nodule, that is, it is classified as Class III or IV by Bethesda, and diagnostic surgery is required. 4) After evaluation by the researchers, there are other surgical indications. 3. There should be sufficient paraffin-embedded tissue or section samples after thyroid surgery available for multi-gene molecular detection 4. Age >=18 years old 5. The specimens from thyroid surgery resection have corresponding postoperative routine pathological diagnosis reports
Exclusion criteria
Exclusion criteria: 1.Patients without postoperative histopathological diagnosis results 2. Patients without preoperative FNA puncture cytological molecular test results 3. Patients who have not undergone surgical treatment in this hospital
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Molecular Mutation Landscape of Thyroid Nodules;The proportion of high molecular risk group (high MRG); | — |
Secondary
| Measure | Time frame |
|---|---|
| The molecular mutation profile of samples with inconsistent preoperative and postoperative BRAF V600E test results;The proportion of intermediate molecular risk group (intermediate MRG); | — |
Countries
China
Contacts
Public ContactZhuoying Wang
Renji Hospital, School of Medicine in Shanghai Jiao Tong University, Shanghai
Outcome results
None listed