Adolescent depression
Conditions
Interventions
rTMS group:The treatment combining rTMS and sertraline
Sham stimulation group:Sham stimulation combined with sertraline treatment
Sponsors
The Affiliated Xuzhou Oriental Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1.The patient meets the diagnostic criteria for depression in the International Classification of Diseases, 10th Revision (ICD-11), with an episode duration of at least 2 weeks. 2.Age 12–18 years, Han ethnicity. 3.The 24-item Hamilton Depression Rating Scale (HAMD-24) score is >=20. 4.The patient's personal information, medical history, medication use, and data from various assessment scales are complete and suitable for in-depth analysis. 5.Informed consent has been signed.
Exclusion criteria
Exclusion criteria: 1. Patients with bipolar affective disorder or other mood disorders. 2. Patients with severe somatic or neurological diseases. 3. Patients with contraindications or allergies to the medications used in this study, non-right-handed individuals, those with a history of epilepsy, or those with abnormal electroencephalogram (EEG) findings. 4. Patients with incomplete clinical data or who are unable to cooperate with the treatment. 5. Patients with scalp wounds or trauma, or those with metal implants in the body. 6. Patients with other cognitive impairments that prevent cooperation with treatment or follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| suPAR;CRP;IL-6; | — |
Countries
China
Contacts
Public ContactCaiyi Zhang
The Affiliated Xuzhou Oriental Hospital of Xuzhou Medical University
Outcome results
None listed