Negative emotions
Conditions
Interventions
Group B:The first phase received normal control intervention. After a one-month elution period as stipulated, the second phase received social distancing inte
Group A:The first phase received social distancing intervention. After a one-month washout period as stipulated, the second phase received normal control inte
Sponsors
The Affiliated Brain Hospital, Guangzhou Medical University
Eligibility
Sex/Gender
Male
Age
18 Years to 30 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18-30 years old, male; 2. UCLA Loneliness Scale =43.3 and L scale 12;
Exclusion criteria
Exclusion criteria: 1. Currently smoking and drinking alcohol; 2. Currently suffering from chronic underlying diseases such as hypertension, diabetes, heart disease, or other major physical illnesses; 3. Suffering from mental disorders such as anxiety disorders, depressive disorders, bipolar disorders, schizophrenia, and post-traumatic stress disorder; 4. Suffering from sleep disorders such as insomnia, sleep apnea syndrome, restless legs syndrome, and periodic leg movements; 5. Currently taking medications related to mental illness or sleep disorders, or any other drugs that may interfere with the study endpoint; 6. Currently living alone; 7. Those with severe claustrophobia, or those with metal or magnetic implants in their bodies; 8. Subjects currently undergoing other clinical studies; 9. Disagree to sign the informed consent;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rumination beliefs;Functional differences in brain regions at rest on fMRI;Degree of rumination reaction;Differences in brain region indicators of rumination-induced task-state fMRI;Instantaneous stress, anxiety, sense of control, avoidance, emotions, desire for social contact and degree of boredom; | — |
Secondary
| Measure | Time frame |
|---|---|
| Degree of stress;loneliness;Salivary cortisol, a -amylase (sAA);Degree of anxiety;Sleep rhythm indicators;Degree of depression;Immune-related indicators: including IL-6, IL-1ß, TNFa, CRP; Analysis of peripheral blood mononuclear cells, NLR, CD16+/CD56+ ratio. ;Sleep status indicators;Stress related indicators: including serum cortisol, plasma adrenaline, and norepinephrine.; | — |
Countries
China
Contacts
Public ContactYan Liang
The Affiliated Brain Hospital, Guangzhou Medical University
Outcome results
None listed