Allergic rhinitis
Conditions
Interventions
Treatment Group 1:Heat-inactivated, high-dose probiotic yogurt stored at room temperature.
Treatment Group 2:Heat-inactivated, low-dose probiotic yogurt stored at room temperature.
placebo group:Probiotic-free room temperature yoghurt
Sponsors
China Agricultural University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18 to 65 years. (2) Presence of at least two of the following clinical symptoms for more than one hour daily without medication: sneezing, rhinorrhea, nasal congestion, or nasal itching. (3) A history of persistent rhinitis for at least one year. (4) A positive skin prick test (Skin Index >= 0.5) or a positive serological specific IgE antibody test (>= 0.35 kU/L) to at least one of the following common allergens: House Dust Mite or Dermatophagoides farinae. (5) Willingness to participate in the trial and provision of signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Diagnosis of an allergic disease other than allergic rhinitis (e.g., atopic dermatitis, asthma). (2) Presence of comorbid upper respiratory tract infection, sinusitis, or nasal polyps. (3) Currently pregnant, lactating, or planning a pregnancy. (4) History of congenital immunodeficiency. (5) Regular consumption of probiotic supplements or lactobacillus-containing dairy products and known milk allergy or lactose intolerance. (6) Use of antihistamines or intranasal corticosteroids within one week prior to enrollment; or use of oral corticosteroids within three months prior to enrollment. (7) A history of allergen immunotherapy or regular use of anti-inflammatory drugs. (8) Having received any vaccination within the three months prior to enrollment. (9) Concurrent participation in another clinical trial and deemed by the investigator to be unsuitable for the trial for any other reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total Nasal Symptoms Score;Immunoglobulin E; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rhinitis Control Assessment Test;Eosinophil;Intestinal metabolites;Gut flora;Rhinoconjunctivitis Quality of Life Questionnaire;Immune cells;Inflammatory cytokines; | — |
Countries
China
Contacts
Public ContactJingjing He
China Agricultural University
Outcome results
None listed