Bronchiectasis
Conditions
Interventions
The Bronchiectasis with Hypercapnia Group:N/A
The Bronchiectasis without Hypercapnia Group:N/A
Sponsors
The First Affiliated Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Inclusion criteria for the bronchiectasis with hypercapnia group (exposure group): 1) Age of 18 years or older, with no restrictions on gender and race; 2) Have a clinical history of bronchiectasis and be diagnosed as bronchiectasis by researchers through HRCT, and confirmed by at least two independent radiologists; 3) Be in the acute exacerbation stage and, at sea level and breathing indoor air, the arterial blood gas analysis shows that the arterial blood carbon dioxide partial pressure (PaCO2) is >= 45 mmHg; 4) Be admitted within 72 hours after the onset of the disease; 5) Be able to independently complete the necessary arterial blood gas analysis, pulmonary function, TTE and other auxiliary examinations for the trial; 6) Voluntarily join this study, be able to independently communicate through language or writing, and be able to understand and sign the contents of the patient's informed consent form. (2) Inclusion criteria for the bronchiectasis without hypercapnia group (control group): 1) Age of 18 years or older, with no restrictions on gender and race; 2) Have a clinical history of bronchiectasis and be diagnosed as bronchiectasis by researchers through HRCT, and confirmed by at least two independent radiologists; 3) Be in the acute exacerbation stage and, at sea level and breathing indoor air, the arterial blood gas analysis shows that the arterial blood carbon dioxide partial pressure (PaCO2) is < 45 mmHg; 4) Be admitted within 72 hours after the onset of the disease; 5) Be able to independently complete the necessary arterial blood gas analysis, pulmonary function, TTE and other auxiliary examinations for the trial; 6) Voluntarily join this study, be able to independently communicate through language or writing, and be able to understand and sign the contents of the patient's informed consent form.
Exclusion criteria
Exclusion criteria: (1) Include other systemic diseases that may cause hypercapnia or affect prognosis: 1) Active pulmonary tuberculosis, lung cancer, pulmonary fibrosis, large pleural effusion, etc.; 2) Diagnosed as idiopathic pulmonary hypertension by right heart catheterization; 3) Moderate to severe aortic valve, mitral valve, tricuspid valve and pulmonary valve heart diseases (in accordance with international guidelines); (2) Include severe organ dysfunction or systemic diseases: 1) Had a history of left heart failure before enrollment; 2) Severe liver or kidney dysfunction (Child-Pugh grade C; or estimated glomerular filtration rate eGFR < 30 mL/min/1.73m²); 3) End-stage disease (such as expected life < 6 months); (3) Other exclusion criteria: 1) Age < 18 years; 2) Pregnant or lactating women; 3) Patients participating in other interventional clinical trials; 4) Any situation that cannot cooperate with the completion of study follow-up (such as mental disorder, long-term residence in another place, etc.); 5) Unable or refusing to provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tricuspid Regurgitation Gradient; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pulmonary Artery Systolic Pressure (PASP);BNP;Right Ventricular Diameter;Right Atrial Pressure (RAP);Interventricular Septal Thickness;Days alive and out of hospital(DAOH);Right Atrial Area;Left Ventricular Diameter;Left Ventricular to Right Ventricular Size Ratio;Tricuspid Annular Plane Systolic Excursion(TAPSE); | — |
Countries
China
Contacts
Public ContactCao Chao
The First Affiliated Hospital of Ningbo University
Outcome results
None listed