Precocious puberty
Conditions
Interventions
Case series:None
Sponsors
The Second Affiliated Hospital of Xi’an Jiaotong University
Eligibility
Sex/Gender
Female
Age
5 Years to 10 Years
Inclusion criteria
Inclusion criteria: 1. Clinical manifestations and ancillary examinations meet the diagnostic criteria outlined in the Guidelines for the Diagnosis and Treatment of Precocious Puberty; 2. Female patients; 3. Guardians voluntarily sign the informed consent form. 4.Girls with central precocious puberty exhibit basal serum LH levels reaching pubertal thresholds (LH > 3.0–5.0 mIU/ml) or demonstrate a positive GnRH stimulation test. Those with incomplete precocious puberty show a negative GnRH stimulation test result.
Exclusion criteria
Exclusion criteria: 1. Concurrent central nervous system abnormalities; 2. Presence of skeletal, cutaneous or other systemic malformations, distinctive facial features, or family history of precocious puberty; 3. Concurrent malignant tumours, intellectual disability, short stature, or other genetic metabolic disorders; 4. History of prolonged corticosteroid use; 5. Presence of liver, thyroid, or renal disease; 6. Diagnosis of peripheral precocious puberty; 7. Initiation of treatment following confirmed diagnosis of precocious puberty.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| melatonin;Perfluoroalkyl and polyfluoroalkyl substances;Follicle-stimulating hormone;Luteinising hormone;Estrogen; | — |
Countries
China
Contacts
Public ContactJing Zhou
The Second Affiliated Hospital of Xi’an Jiaotong University
Outcome results
None listed