Severe pneumonia
Conditions
Interventions
Experimental group:Participants in the intervention group will receive inn at 200 ppm two times daily, with each session
lasting 30 min, for 5 days, beginning within 24 h of enrollment
Control group:Standard treatment plus sham inhaled nitric oxide (NO)
Sponsors
Jiangdu People's Hospital Affiliated to Yangzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age 18 years or older. 2. Diagnosis of severe pneumonia within 24 h before enrolment. 3. Requirement for invasive mechanical ventilation. 4. Suspected or conffrmed infection caused by multidrug-resistant (MDR) bacteria; confirmation may be based on sputum or bronchoalveolar lavage fluid (BALF) culture. 5. Written informed consent provided by the patient or a legally authorized representative.
Exclusion criteria
Exclusion criteria: 1. Currently participating in another clinical trial; 2. Active pulmonary malignancy, or a history of lung transplantation or lung resection; 3. Severe burns involving more than 40% of the total body surface area; 4. Severe hepatic or renal dysfunction, defined as Child–Pugh class C liver disease or an estimated glomerular filtration rate (eGFR) <30 mL/min; 5. Currently receiving renal replacement therapy; 6. Previous treatment with inhaled nitric oxide (NO) before enrollment; 7. Presence of methemoglobinemia; 8. Major bleeding at the time of screening.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in CPIS from baseline to day 7; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality Rate;ventilator-free days through day 28;vasopressor-free days through day 28;antibiotic-free days through day 28;ICU -free days through day 28;hospital-free days through day 28.;CPIS scores;SOFA scores;microbiological eradication rate;citrullinated histone H3;cell-free DNA;Pao2/FiO2;Methemoglobin;NO2;Creatinine;Airway hyperresponsiveness events;Incidence of acute kidney injury (AKI); | — |
Countries
China
Contacts
Public ContactPenglei Yang
Jiangdu People's Hospital Affiliated to Yangzhou University
Outcome results
None listed