Scarring alopecia
Conditions
Interventions
Experimental group of scalp tissue:Co-culture with Anti-IL-12/23 monoclonal antibody
Control group of scalp tissue:Co-culture with Anti-IL-12/23 monoclonal antibody
Experimental group of hair follicles:Co-culture with Anti-IL-12/23 monoclonal antibody
Sponsors
Jing'an District Central Hospital Of Shanghai
Eligibility
Sex/Gender
Male
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) male aged 18-60 years; (2) patients who were ready for hair transplantation voluntarily participated in hair follicle tissue extraction; Or patients with LPP or scalp psoriasis who are ready for biopsy, voluntarily participate in scalp tissue extraction; (3) have good compliance, understanding ability, and voluntarily sign informed consent.
Exclusion criteria
Exclusion criteria: (1) patients with acute advanced alopecia; (2) patients who received systemic immunosuppressants within the past 3 months; (3) patients with severe infection or malignant tumors on the scalp; (4) patients with serious heart, lung, liver, kidney, blood and other important organ system diseases, malignant tumors, nervous and mental diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflammatory markers of scalp tissues;EMT-related markers in hair follicles;PPAR-? pathway analysis in hair follicles;Scalp thickness, collagen thickness, changes in hair follicle number;Transcriptomic analysis of scalp tissues;Fibrosis markers of scalp tissues; | — |
Countries
China
Contacts
Public ContactWenyu Wu
Jing'an District Central Hospital Of Shanghai
Outcome results
None listed