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Association between gut metabolites of the trimethylamine pathway, white matter lesions, and thrombectomy for acute large vessel occlusion cerebral infarction

A study on the association of gut metabolites in the trimethylamine pathway and white matter lesions with the prognosis of mechanical thrombectomy for acute anterior circulation cerebral infarction

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500112173
Enrollment
Unknown
Registered
2025-11-11
Start date
2023-12-10
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebrovascular disease

Interventions

Observation group:None

Sponsors

The Affiliated Hospital of Xuzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Acute ischemic stroke with imaging-confirmed large artery occlusion. 2. CT scan excludes intracranial hemorrhage. 3. For anterior circulation occlusion, symptom onset is within 6 hours; for anterior circulation occlusion with symptom onset between 6–24 hours or posterior circulation large vessel occlusion within 24 hours, endovascular therapy may be performed after strict imaging selection. 4. The patient or legal representative provides signed informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients with severe active bleeding or known significant bleeding tendency. 2. Severe dysfunction of major organs (e.g., heart, liver, or kidneys). 3. Expected survival <90 days based on clinical assessment and diagnostic findings.

Design outcomes

Primary

MeasureTime frame
Trimethylamine N-oxide;—

Countries

China

Contacts

Public ContactZhu Shiguang

The Affiliated Hospital of Xuzhou Medical University

Sgzhuxyfy@126.com+86 158 5239 0076

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026