Stroke
Conditions
Interventions
Moderate - intensity Aerobic Exercise Group:Carry out moderate - intensity aerobic exercise intervention. The exercise forms are treadmill running or stationary bicycle riding. The exercise intensity
Low - intensity Aerobic Exercise Group:Carry out low - intensity aerobic exercise intervention. The exercise forms are treadmill running or stationary bicycle riding. The exercise intensity is control
Sponsors
The Second Affiliated Huai'an Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
35 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.All enrolled stroke patients meet the Diagnostic Criteria for Various Cerebrovascular Diseases revised by the Chinese Medical Association and are clearly diagnosed by cranial CT or MRI (including ischemic and hemorrhagic stroke). 2.Aged 35 - 75 years. 3. First - episode disease without progressive illness, with mild post - stroke cognitive impairment (PSCI) meeting the diagnostic criteria for mild PSCI: Montreal Cognitive Assessment (MoCA) score of 21 - 26 (considering education level correction: for those with <= 12 years of education, add 1 point and still within the range of 21 - 26); or Mini - Mental State Examination (MMSE) score stratified by education level: illiterate 17 - 21 points, primary school 20 - 23 points, middle school and above 24 - 26 points; cognitive impairment occurs or significantly worsens after stroke, excluding pre - existing cognitive impairments such as dementia and Alzheimer's disease. 4.Have mild impairment in at least 1 cognitive domain (such as executive function, memory, attention).(5) Instrumental Activities of Daily Living (IADL) score <= 2 (cognitive impairment does not significantly affect basic self - care in daily life, only minor impairment in complex tasks). 6.Conscious, able to understand and cooperate to complete cognitive assessment, neuroimaging examinations (such as fMRI) and exercise training. 7. Patients in the subacute phase of stroke with stable condition within 1 - 6 months of disease duration (during this phase, cognitive function changes significantly, which is convenient for observing the intervention effect).8.Have not participated in similar studies before. 9.Agree to participate in this trial, sign the informed consent form and have complete data.
Exclusion criteria
Exclusion criteria: 1.Patients who refuse to accept random grouping. 2.Patients with severe limb dysfunction (e.g., muscle strength of the affected limb <= Grade 3, unable to independently complete walking or fixed bicycle training) and unable to cooperate with exercise intervention. 3.Patients with other severe physical diseases who cannot tolerate training. 4.Patients who cannot complete magnetic resonance imaging (MRI) examinations. 5.Pre-stroke cognitive impairment: such as pre-stroke diagnosed dementia, Alzheimer's disease, or other neurodegenerative diseases. 6.Other causes of cognitive impairment: such as Parkinson's disease, encephalitis, brain tumors, thyroid dysfunction, vitamin B12 deficiency, severe depression, etc. 7.Patients with moderate to severe Post-Stroke Cognitive Impairment (PSCI) (MoCA score < 21, or MMSE score lower than the lower limit of the mild range corresponding to education level stratification).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment (MoCA) Score;Functional Magnetic Resonance Imaging (fMRI) Brain Function Index;Victoria Stroop Test; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini - Mental State Examination (MMSE) ;Rivermead Behavioral Memory Test;Maximal Oxygen Uptake(VO?max);Heart Rate Reserve(HRR); | — |
Countries
China
Contacts
Public ContactLi Xuejing
The Second Affiliated Huai'an Hospital of Xuzhou Medical University
Outcome results
None listed