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A Multicenter Study on the Effects of Continuous Renal Replacement Therapy on Exosomes in Children with Sepsis

A Multicenter Study on the Effects of Continuous Renal Replacement Therapy on Exosomes in Children with Sepsis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500112145
Enrollment
Unknown
Registered
2025-11-11
Start date
2025-12-01
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Interventions

CRRT treatment group:None
Conventional treatment group:None

Sponsors

Shanghai Children's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 18 Years

Inclusion criteria

Inclusion criteria: 1.Age: birth to 18 years old; 2.No severe underlying comorbidities; 3.Newly diagnosed with sepsis; 4.CRRT initiated within 24 hours of diagnosis; 5.CRRT support sustained for at least 24 hours.

Exclusion criteria

Exclusion criteria: 1.Patients diagnosed with sepsis for over 48 hours upon PICU admission; 2.Use of corticosteroids, immunosuppressants, or similar medications within the past six months; 3.Presence of severe primary diseases in vital organs (e.g., heart, liver, or kidney); 4.Inability to provide informed consent.

Design outcomes

Primary

MeasureTime frame
Exosome counts;—

Secondary

MeasureTime frame
Blood routine examination;—

Countries

China

Contacts

Public ContactYucai Zhang

Shanghai Children's Hospital

zhangyc@shchildren.com.cn+86 21 52976653

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026