Non-infectious skin diseases
Conditions
Interventions
Lactobacillus crispatus smear test group:Once daily, 3mL of Lactobacillus crispatus solution was applied to the bilateral forearms at a diameter of 3cm 10cm from the carpal wrinkles
Inactive Lactobacillus crispatus smear controls:Once daily, 3mL of inactive Lactobacillus crispatus solution was applied to the bilateral forearms at a diameter of 3cm 10cm from the carpal wrinkles
Sponsors
Shenzhen People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. meet the 2020 World Health Organization (WHO) criteria for obesity classification: normal weight: BMI 18.5-24.9 kg/m^2; Overweight: BMI 25-29.9 kg/m^2; Obesity: BMI >= 30 kg/m^2, no duration limitation; 2. Skin barrier damage (such as dry skin, erythema, desquamation, pruritus, etc.); 3. patients' informed consent and voluntary participation; Signing informed consent; 4. aged 18-45 years with good general health; 5. not using drugs that affect the skin barrier (such as hormones and immunosuppressants) within 3 months ", and clearly "allowing the use of drugs for underlying diseases that do not affect the skin (such as antihypertensive drugs and hypoglycemic drugs); 6. no skin disease or trauma.
Exclusion criteria
Exclusion criteria: 1. history of allergy or allergy to probiotics, placebo, or study drug; 2. patients with active skin disease or other serious diseases; 3. pregnant or lactating women; 4. use of drugs that may affect skin barrier function (such as hormone drugs, immunosuppressants, etc.); 5. other circumstances considered by the investigator to be inappropriate for subject inclusion, such as the subject being untrustworthy, unacceptable, or unable to understand the evaluator of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Transepidermal water loss rate of forearm skin; | — |
Secondary
| Measure | Time frame |
|---|---|
| Skin hydration;Skin health score;Analysis of the skin microbiota;Body Weight and BMI;Detection of Inflammatory Factors;Assessment of Quality of Life; | — |
Countries
China
Contacts
Public ContactJianglin Zhang
Shenzhen People’s Hospital (The First Affiliated Hospital, Southern University of Science and Techno )
Outcome results
None listed