Chronic neuropathic pain
Conditions
Interventions
Healthy control group:None
CNP without cognitive impairment group:None
CNP with cognitive impairment group:None
Sponsors
The Affiliated Hospital of Southwest Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age >=18 years old <=65 years old 2. Meet the diagnostic criteria for peripheral chronic neuropathic pain (including trigeminal neuralgia, postherpetic neuralgia, phantom limb pain and complex regional pain syndrome) 3. The duration of CNP exceeds three months 4. There are no primary organic diseases in the intracranial cavity 5. Patients with cognitive impairment: Mini-Mental State Examination (MMSE)<24 points and Montreal Cognitive Assessment Scale (MoCA)<26 points 6. Informed consent forms have been signed
Exclusion criteria
Exclusion criteria: 1. Those who have not obtained the consent of the patient or guardian to extract data 2. History of previous head trauma or surgery 3. Individuals with a history of cerebrovascular disease 4. Patients who are currently taking vascular or psychiatric medications during the visit 5. Patients currently participating in other clinical studies 6. Patients who cannot fully understand the content of the scale 7. Patients with infectious diseases If the skin lesions of herpes zoster patients have not healed, even if they meet the diagnostic criteria for PHN, they are excluded 9. Individuals with severe liver and kidney dysfunction 10. Individuals with a history of malignant tumors
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cold-induced RNA-binding protein; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tumor necrosis factor-a;Interleukin-6;Interleukin-1ß;Interleukin-10;Neuron specific enolase (NSE);Central nervous system specific proteins; | — |
Countries
China
Contacts
Public ContactJun Zhou
The Affiliated Hospital of Southwest Medical University
Outcome results
None listed