Postoperative pain after laparoscopic surgery.
Conditions
Interventions
Medium-dose anrikefon group:Medium-dose anrikefon-based patient-controlled analgesia
Morphine group:Morphine-based patient-controlled analgesia
High-dose anrikefon group:High-dose anrikefon-based patient-controlled analgesia
Low-dose anrikefon group:Low-dose anrikefon-based patient-controlled analgesia
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 74 Years
Inclusion criteria
Inclusion criteria: 1.Aged = 18 years but < 75 years; 2.Scheduled to undergo elective laparoscopic gastrointestinal surgery with an expected duration of =1 hour; 3.The incisional pain can be covered by the transversus abdominis plane block or rectus sheath block; yet patients still require postoperative patient-controlled intravenous analgesia.
Exclusion criteria
Exclusion criteria: 1.Presence of preoperative cognitive impairment (Mini-Mental State Examination [MMSE] score 30 kg/m² or 180 mmHg and/or diastolic blood pressure (DBP) > 110 mmHg, coronary artery disease with unstable angina or myocardial infarction within 6 months, heart failure rated as New York Heart Association classification = III, severe chronic obstructive pulmonary disease (or in a state of acute exacerbation), severe hepatic insufficiency (Child-Pugh grade C), severe renal insufficiency (estimated glomerular filtration rate = IV; 4.Continuous use of opioid analgesics for more than 10 days for any reason, or alcohol abuse (average daily intake of pure alcohol > 36 g) within 3 months before screening; 5.Preoperative use of opioid or non-opioid analgesics with the interval between the last administration and randomization shorter than five half-lives of the drug or the duration of drug action (whichever is longer); 6.Known allergies or contraindications to opiates or other medications that may be used in this study, such as anesthetics, antiemetics, and nonsteroidal anti-inflammatory drugs (NSAIDs); 7.Anticipated need for postoperative mechanical ventilation; 8.Other conditions that are considered unsuitable for study participation;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time-weighted sum of pain intensity difference (SPID) of movement-evoked visceral pain within 48 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time-weighted SPID of overall pain with movement or at rest within 48 hours;Time-weighted SPID of somatic pain with movement or at rest within 48 hours;Time-weighted SPID of visceral pain at rest within 48 hours; | — |
Countries
China
Contacts
Public ContactDong-Xin Wang
Peking University First Hospital
Outcome results
None listed