Postoperative frailty
Conditions
Interventions
Observation group:None
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: Age >= 60 years; Patients undergoing elective grade 4 abdominal surgery during general surgery hospitalization; Agree to provide saliva and fecal samples.
Exclusion criteria
Exclusion criteria: There was severe intestinal flora imbalance before the surgery; patients with severe infections requiring long-term anti-infection treatment; those who received probiotic preparations within 3 months; patients with severe oral diseases and a history of oral inflammation (evaluation criteria: 1) Clinical diagnostic criteria: active periodontitis (periodontal pocket depth = 5mm, bleeding on probing); oral ulcer area = 1cm² or lasting > 2 weeks; acute suppurative parotitis or maxillofacial cellulitis; severe caries, involving the dental pulp or requiring root canal treatment. 2) Auxiliary examinations: The oral doctor confirmed through clinical examination and imaging (such as panoramic X-ray) assessment; there were severe heart, lung, liver, and kidney function impairments (evaluation criteria strictly follow the definitions of severe organ dysfunction in international authoritative guidelines: cardiac function using NYHA III-IV grade or ACC/AHA Stage C-D period; pulmonary function based on GOLD 3-4 grade; liver function referring to Child-Pugh C grade or liver function test indicators more than twice the normal value; kidney function based on KDIGO G4-G5 stage to ensure the safety of the study population and the reliability of the data).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement rate of frailty; | — |
Secondary
| Measure | Time frame |
|---|---|
| Other clinical outcomes (changes in body weight and body composition, post-discharge complications, re-hospitalization situations);Two groups of inflammatory indicators;Immune status;Change in nutritional status; | — |
Countries
China
Contacts
Public ContactMingwei Zhu
Beijing Hospital
Outcome results
None listed