Graves’ disease
Conditions
Interventions
Patients with Graves’ Disease:None
Patients with Hashimoto’s Thyroiditis:None
Patients with Subacute Thyroiditis:None
Patients with Thyroid Nodules:None
Sponsors
Guangdong Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria Patients aged >=18 years, excluding pregnant women, with complete and traceable background information. 1. Patients with Graves' Disease (GD): (1) Elevated serum thyroid hormone levels and decreased TSH levels; (2) Diffuse enlargement of the thyroid gland; (3) At least one of the following: 1) Eyelid retraction and other clinical signs suggestive of Graves' ophthalmopathy (GO); 2) Dermal mucinosis, such as pretibial myxedema or acropachy; 3) Increased radioactive iodine uptake on thyroid scintigraphy; (4) Negative or low-titer TPOAb and TgAb. 2. Patients with Hashimoto's Thyroiditis: (1) Serum TPOAb > 500 IU/mL and diffuse heterogeneous echotexture on thyroid ultrasound; (2) Normal or reduced thyroid hormone levels at present. 3. Subacute Thyroiditis: Meeting at least 4 of the following 6 criteria: (1) Acute onset, often accompanied by symptoms and signs of upper respiratory tract infection; (2) Painful, enlarged, and firm thyroid gland; (3) Accelerated erythrocyte sedimentation rate (ESR); (4) Dissociation between elevated serum thyroid hormone levels and reduced thyroid iodine uptake; (5) Transient thyrotoxicosis; (6) Negative or low-titer TgAb and TPOAb. 4. Thyroid Nodules: (1) Normal thyroid function at present; (2) Negative TgAb and TPOAb; (3) Ultrasound shows focal echogenic changes consistent with thyroid nodules (not diffuse abnormalities), with size >5 mm. 5. Healthy Individuals: (1) Normal thyroid function; (2) Negative TgAb and TPOAb; (3) Ultrasound shows normal thyroid size and nearly normal echotexture; (4) No use of medications affecting thyroid function.
Exclusion criteria
Exclusion criteria: 1. Samples with incomplete information that cannot be traced. 2. Samples with insufficient volume for testing. 3. Samples that do not meet the requirements for collection and storage. Healthy individuals should be excluded if they have had recent surgery, hospitalization, drug abuse, or other potential confounding factors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Thyroid Stimulating Hormone Receptor Antibody;Diagnostic Performance of the TRAb Assay Kit; | — |
Countries
China
Contacts
Public ContactGuan Haixia
Guangdong Provincial People's Hospital
Outcome results
None listed