Perioperative sleep disorders
Conditions
Interventions
Group L:Ultrasound-guided injection of 5 ml mixture of dexmedetomidine (0.25 µg/kg, Enhua Pharma) in saline near the operative-side stellate ganglion preoperatively.
Group M:Ultrasound-guided injection of 5 ml mixture of dexmedetomidine (0.5 µg/kg, Enhua Pharma) in saline near the operative-side stellate ganglion preoperatively.
Group H:Ultrasound-guided injection of 5 ml mixture of dexmedetomidine (0.75 µg/kg, Enhua Pharma) in saline near the operative-side stellate ganglion preoperatively.
Group C:Ultrasound-guided injection equivalent dose of 5 ml 0.9% saline near the operative-side stellate ganglion preoperatively.
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1. Age range: 60-79 years; 2. ASA classification II-III; 3. Scheduled for thoracoscopic lobectomy; 4. Patients who sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Individuals with contraindications to regional puncture( infections around the puncture site, and coagulation disorders: such as PLT1.5); 2. Individuals who have experienced any cerebrovascular accidents within the past 3 months, such as stroke or transient ischemic attack (TIA); 3. Patients with language communication disorders or mental disorders; 4. Patients with severe bradycardia or II-III degree atrioventricular block; 5. Individuals with contraindications to experimental drugs and other anesthetics; 6. Identify patients with sleep disorder prior to surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of sleep disturbances within 3 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep Quality Numeric Rating Scale (NRS) scores on the morning of postoperative days 1, 2, 3 and 7;Pittsburgh Sleep Quality Index (PSQI) score;Postoperative sleep (sleep duration, and the duration and proportion of deep sleep, light sleep, REM sleep);Hospital Anxiety and Depression Scale score;Pain VAS score within the first 3 postoperative days;Incidence of intraoperative hypotension, bradycardia, hypertension and tachycardia.;Postoperative adverse reactions (respiratory depression, nausea and vomiting, hypotension, bradycardia, etc.);Intraoperative hemodynamic indexes;Hospital stay, LOS;Intraoperative Heart Rate Variability;Athens Insomnia Scale (AIS) scores on the morning of postoperative days 1, 2, 3 and 7; | — |
Countries
China
Contacts
Public ContactCheng Xinqi
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed