metabolic dysfunction-associated steatotic liver disease
Conditions
Interventions
Index test:gut microbiota 16rRNA sequencing
Sponsors
Shanghai Sixth People`s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients with Non-alcoholic fatty liver disease (NAFLD) confirmed by liver biopsy, who meet the following criteria: 1) Age greater than 18 years. 2) Liver histopathology demonstrates hepatic steatosis with ballooning degeneration and lobular inflammation, with or without liver fibrosis. Liver fibrosis grading: Liver tissue fibrosis is graded according to the SAF diagnostic scoring system of the European Fatty Liver Collaboration Group, with grades 0–2 indicating mild fibrosis and grades 3–4 indicating advanced fibrosis.
Exclusion criteria
Exclusion criteria: 1) Excessive alcohol consumption (alcohol intake >30 g/day for men and >20 g/day for women). 2) Patients with concomitant viral hepatitis. 3) Patients with other non-viral liver diseases including drug-induced liver injury, autoimmune hepatitis, and Wilson's disease. 4) Patients with thyroid dysfunction or polycystic ovary syndrome (PCOS).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gut microbiota 16rRNA sequencing;Accuracy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensitivity;Specificity;Positive predicative value;negative predictive value; | — |
Countries
China
Contacts
Public ContactLi Hu
Shanghai Sixth People`s Hospital
Outcome results
None listed