Hyperlipidemic Acute Pancreatitis (HLAP) is a special subtype of acute pancreatitis caused by significantly elevated levels of triglycerides (TG) in the blood. Patients often present with primary or secondary hypertriglyceridemia, with TG levels commonly exceeding 1000 mg/dL (approximately 11.3 mmol/L). The clinical symptoms are similar to other types of acute pancreatitis and include persistent a
Conditions
Interventions
Experimental group 1:Fenofibrate + Akkermansia muciniphila PROBIO live bacteria
control group:Fenofibrate + placebo
Experimental group 2:Fenofibrate + Akkermansia muciniphila PROBIO postbiotic
Sponsors
The first affiliated hostipal of nanchang university
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18–65 years, regardless of sex. 2.Body Mass Index (BMI) >= 24.0 kg/m^2; 3.Diagnosed with hyperlipidemic acute pancreatitis, defined as: Meeting diagnostic criteria for acute pancreatitis; Serum triglyceride level >= 11.3 mmol/L; Other causes of acute pancreatitis excluded. 4.Currently in the recovery phase of pancreatitis (symptom relief, controlled inflammation, recovery of organ function, and improvement on imaging). 5.Fasting triglycerides > 5.65 mmol/L at enrollment; 6.Signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Known allergy to probiotic products; 2.Combined uncontrolled infection or severe organ failure; 3.History of antibiotic, probiotic, or immunosuppressant use within the past 2 weeks; 4.History of intestinal surgery, inflammatory bowel disease, or other conditions affecting gut microbiota; 5.Pregnant or breastfeeding women;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Triglyceride Compliance Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in gut microbiota composition;Triglyceride Compliance Rate;adverse event rate;BMI change rate;Recurrence rate of pancreatitis; | — |
Countries
China
Contacts
Public ContactHu Yi
The first affiliated hostipal of nanchang university
Outcome results
None listed