Painless prostate biopsy
Conditions
Interventions
Propofol and Remifentanil group(R group):Remifentanil
Propofol and Esketamine group(E group):Esketamine
Propofol and Ozelidine Group(O group):Ozelidine
Sponsors
Shanghai Changhai Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for transperineal prostate biopsy; 2. Age 18–85 years; 3. Body Mass Index (BMI) 18–30 kg/m^2 ; 4. American Society of Anesthesiologists (ASA) classification I–III; 5. Preoperative assessment indicates no difficult airway.
Exclusion criteria
Exclusion criteria: 1. Patient refuses to participate in the study; 2. History of severe heart, brain, lung, liver, kidney, or metabolic diseases; 3. Patients with gastrointestinal obstruction or high risk of reflux aspiration; 4. History of abnormal surgical anesthesia recovery; 5. Patients with sinus bradycardia or atrioventricular block; 6. History of acute respiratory inflammation within 2 weeks that has not been cured; 7. Preoperative hypertension patients >180/90 mmHg or hypotension patients <90/60 mmHg; 8. Patients with neuromuscular disorders or mental illnesses; 9. Hemoglobin level below 90 g/L; 10. Suspected abuse of narcotic analgesics or sedatives; 11. Predicted or previously experienced difficult airway; 12. Known allergy to oliceridine, opioids, or esketamine; 13. Concurrent use of other sedative or analgesic drugs within 15 minutes before, during, or after surgery (including injections, oral drugs, and related traditional Chinese medicine); 14. Uncooperative or unable to communicate patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EC95 of Remifentanil in the R group;Degree of respiratory depression;EC95 of Esketamine in the E group;EC95 of Oxeladin in the O group; | — |
Secondary
| Measure | Time frame |
|---|---|
| Each group's EC50;Patient and operator satisfaction;Administer an additional dose of propofol;Lowest blood oxygen saturation;Loop parameter; | — |
Countries
China
Contacts
Public ContactYi Zhou
Shanghai Changhai Hospital
Outcome results
None listed