Parkinson's disease and Parkinson-Plus Syndromes
Conditions
Interventions
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: Participants should meet the following criteria: 1. Provide a signed and dated informed consent form; 2. Agree to comply with study procedures and participate in the entire research process; 3. Aged between 50 and 80 years; 4. Meet the diagnostic criteria and exhibit the characteristic symptoms and signs of specific diseases (e.g., PD, MSA, DLB, CBD, PSP), or be generally in good health; 5. Have adequate physical, cognitive, auditory, speech, literacy, and language abilities to complete all required assessments.
Exclusion criteria
Exclusion criteria: Participants will be excluded if they meet any of the following criteria: 1. Presence of other neurological disorders such as cerebrovascular disease, traumatic brain injury, major systemic diseases (e.g., hepatic or pulmonary encephalopathy), or intracranial space-occupying lesions (e.g., subdural hematoma, brain tumor); 2. Evidence of significant structural brain abnormalities, including ischemic infarction, subdural hematoma, intracranial hemorrhage, hydrocephalus, brain tumor, multiple subcortical ischemic lesions, or a single lesion in critical regions (e.g., thalamus). Mild, clinically insignificant white matter changes or no more than two lacunar infarctions are acceptable; 3. Inability to undergo MRI scanning due to conditions such as claustrophobia or cardiac pacemaker implantation; 4. Psychiatric disorders diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) within the past 12 months that are unstable or could interfere with study assessments, including schizophrenia or other psychotic disorders, bipolar disorder, major depressive disorder, or delirium; 5. Diagnosis of alcohol or substance abuse or dependence within the past 12 months based on DSM-V criteria; 6. Poor compliance or inability to complete the study as judged by the investigators; 7. Inability to undergo MRI or PET imaging.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biomarkers and digital biomarkers differentiating PD subtypes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Biomarkers and digital biomarkers for differentiating PD from PDS; | — |
Countries
China
Contacts
Public ContactChen Shengdi
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed