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Pharmacokinetic/pharmacodynamic/toxicodynamic analysis of trimethoprim-sulfamethoxazole in non-HIV patients with Pneumocystis jirovecii pneumonia and Stenotrophomonas maltophilia infection: A multicenter observational study

Pharmacokinetic/pharmacodynamic/toxicodynamic analysis of trimethoprim-sulfamethoxazole in non-HIV patients with Pneumocystis jirovecii pneumonia and Stenotrophomonas maltophilia infection: A multicenter observational study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500112036
Enrollment
Unknown
Registered
2025-11-10
Start date
2025-11-15
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None

Interventions

Observation group (treatment with compound sulfamethoxazole):None

Sponsors

Tongde Hospital of Zhejiang Province
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Age >=18 years; 2.Non-HIV patients or SMA infection patients with imaging, etiological and molecular biological results suggesting PJP; 3.Receiving TMP-SMZ injection treatment; 4.Agreeing to participate in this study and signing the informed consent form;

Exclusion criteria

Exclusion criteria: 1.Those known to be allergic to TMP-SMZ; 2.Those who have used TMP-SMZ for less than 3 days; 3.Patients who do not cooperate with blood collection and related tests at the specified time; 4.Pregnant or lactating women; 5.Other situations where the researcher deems the patient unsuitable for participation in this clinical trial;

Design outcomes

Primary

MeasureTime frame
Clinical efficacy;Microbial clearance;

Secondary

MeasureTime frame
Economic indicators (length of stay, total hospitalization cost, total hospitalization examination cost, total hospitalization drug cost, total hospitalization antibiotic cost, compound sulfamethoxazole cost);Survival and recurrence of infection;Adverse reactions;

Countries

China

Contacts

Public ContactYuexing Tu

Tongde Hospital of Zhejiang Province

Tuyuexing1988@163.com+86 571 89972333

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026