Gastroesophageal reflux disease
Conditions
Interventions
Observation group:None
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age requirement: >=18 years old; 2. Confirmed gastroesophageal reflux disease diagnosis: a) Endoscopically proven reflux esophagitis (Los Angeles classification grade B-D); b) Pathologic acid exposure (acid exposure time > 4%) or reflux episodes > 80 on 24-hour impedance-pH monitoring; 3. Persistent symptoms: Typical reflux symptoms (regurgitation, heartburn, or chest pain); 4. Completed optimal proton pump inhibitors (PPI) therapy (double-dose PPI for >= 8 weeks)
Exclusion criteria
Exclusion criteria: 1. Surgical history: Previous digestive tract surgery (excluding appendectomy or splenectomy); 2. Endoscopically Organic lesions (including Barrett's esophagus or reflux-induced esophageal stenosis); 3. Esophageal motility disorders (e.g., achalasia, Jackhammer esophagus); 4. Systemic comorbidities: Severe cardiac/hepatic/pulmonary/renal disorders, Hematologic/endocrine/neurologic diseases, Active mental illness; 5. Connective tissue disease and uncontrolled diabetes; 6. Special populations: Pregnancy/lactation; 7. Recent antibiotics/acid suppressants use (> 3 consecutive days in past month); 8. Recent probiotics/laxatives/prokinetics use (within 2 weeks); 9. Drug hypersensitivity: Rifaximin/rifamycin allergy history; 10. Declined informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment response rate (defined as a >=50% reduction in RDQ score); | — |
Countries
China
Contacts
Public ContactLiping Duan
Peking University Third Hospital
Outcome results
None listed