amyotrophic lateral sclerosis
Conditions
Interventions
Test group:Suregery, Motor Cortical Electrical Stimulation
Sponsors
Peking University International Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed with ALS 2. Age from 18 to 85 years old; 3. FVC >= 60% expected value; 4. Outpatient completed electromyography and single photon emission computed tomography examinations; 5. Voluntarily joining this study, signing an informed consent form, demonstrating good compliance, and willing to cooperate with follow-up.
Exclusion criteria
Exclusion criteria: 1. Diseases related to surgical contraindications, including but not limited to: severe infection or inflammation, coagulation dysfunction, severe cardiovascular disease; 2. Laboratory tests (blood routine, coagulation function, liver and kidney function, etc.) are abnormal, and the researcher has determined that surgery is not suitable; 3. Imaging examinations such as magnetic resonance imaging (MRI) or computed tomography (CT) cannot determine the anatomical location of the motor cortex based on the researcher's judgment; 4. Metal implants within a stimulation range of 30cm; 5. After implantation of cardiac pacemaker; 6. History of refractory epilepsy in the past, currently epilepsy has not been controlled; 7. Pregnant or lactating women; 8. Previously received deep brain stimulation; 9. Other circumstances deemed unsuitable by the investigator to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in ALS functional scale and baseline after surgery in patients; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the Postoperative Quality of Life Scale from Baseline; | — |
Countries
China
Contacts
Public ContactXianzeng Liu
Peking University International Hospital
Outcome results
None listed