Carotid Stenosis
Conditions
Interventions
Gold Standard:Based on non-contrast high-resolution magnetic resonance imaging (HR-MRI) of the carotid artery, plaque vulnerability assessed using the MRI-PlaqueView™ software [PlaqueView (Beijing) Di
Index test:Based on carotid artery CTA, the spatial distribution characteristics of perivascular adipose tissue at the carotid bifurcation analyzed using Slicer software (v 5.8.1) served as the diagno
Sponsors
The First Medical Center of the PLA General Hospital
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 40 years; 2. Presence of atherosclerotic plaque at the carotid bifurcation or the origin of the internal carotid artery on either side, as detected by ultrasound or carotid artery CTA; 3. Luminal stenosis >= 50% in asymptomatic patients, or >= 30% in symptomatic patients with carotid stenosis (e.g., transient ischemic attack or ischemic stroke); 4. Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. History of previous carotid artery surgery, radiotherapy, or stent implantation; 2. Poor image quality of carotid artery CTA or HR-MRI that is inadequate for post-processing analysis (e.g., severe motion artifacts, insufficient contrast filling, etc.); 3. Coexistence of other non-atherosclerotic vascular diseases (e.g., Takayasu arteritis, arterial dissection, fibromuscular dysplasia, etc.); 4. Severe renal insufficiency (eGFR < 30 ml/min/1.73m^2) precluding contrast-enhanced CTA; 5. Presence of any contraindication to MRI examination (e.g., non-compatible metallic implants, claustrophobia, etc.); 6. Presence of systemic diseases affecting lipid metabolism (e.g., Cushing's syndrome, systemic lupus erythematosus, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The area under the working characteristic curve; | — |
Countries
China
Contacts
Public ContactWang Jun
The First Medical Center of the PLA General Hospital
Outcome results
None listed