Cerebrovascular structural and functional abnormalities and related diseases
Conditions
Interventions
Propranolol combined with Metoclopramide treatment group:Propranolol 10 mg + metoclopramide 5 mg + normal saline 10ml nasal feeding, three times a day
standard acute cerebral infarction treatment program (including antiplatelet or anticoagulation, lipid regulation, etc.) or standard cerebral hemorrhage treatment program, standard nasogastric enteral
Propranolol group:Propranolol 10 mg + normal saline 10 ml was administered by nasogastric feeding three times a day
standard acute cerebral infarction treatment regimen (including antiplatelet or anticoagulation, lipid regulation, etc.) or standard cerebral hemorrhage treatment regimen, standard nasogastric enteral
Metoclopramide group:Metoclopramide 5 mg + normal saline 10ml nasal feeding, three times a day
Sponsors
Quanzhou First Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Diagnosis meets the diagnostic criteria for acute cerebral infarction in the "Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2018" or the diagnostic criteria for cerebral hemorrhage in the "Chinese Guidelines for the Diagnosis and Treatment of Cerebral Hemorrhage 2019"; 2. Age > 18 years; 3. Onset time < 48 hours; 4. Swallowing difficulty determined by the Watanabe water swallowing test, requiring nasogastric feeding.
Exclusion criteria
Exclusion criteria: 1. Presence of contraindications to propranolol or metoclopramide; 2. Dysphagia prior to onset; 3. Existing infection at the time of admission; 4. Use of ß-blockers (including selective and non-selective ß-blockers), metoclopramide, or antibiotics within the past 7 days; 5. Patients with an expected survival of no more than 14 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the severity of stroke; | — |
Secondary
| Measure | Time frame |
|---|---|
| swallowing function; | — |
Countries
China
Contacts
Public ContactPingzhen Lin
Quanzhou First Hospital
Outcome results
None listed