Alzheimer‘s disease
Conditions
Interventions
Participant group and control group:None
Sponsors
Quangang District General Hospital, First Affiliated Hospital of Fujian Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.Age 40–90 years; 2.Primary or comorbid diagnosis of cognitive impairment, presenting with memory decline, inattention, executive dysfunction, or personality changes; 3.Complete cognitive assessments, able to complete MoCA (or Mini-MoCA) and MMSE; 4.Able to communicate and complete questionnaires independently or with family assistance (including PHQ-9); 5.Written informed consent obtained from the participant or legal guardian, with brain MRI results available within the past 12 months and blood test available within 3 months.
Exclusion criteria
Exclusion criteria: 1.History of stroke or cerebrovascular disease: confirmed ischemic or hemorrhagic stroke, severe intracranial arterial stenosis (>=70%) or occlusion, or focal neurological deficits related to vascular lesions; 2.Moderate-to-severe depression (PHQ-9 > 10) or acute phase of severe psychiatric disorders; 3.Other conditions known to cause cognitive impairment: infectious (e.g., neurosyphilis, HIV), endocrine/metabolic (e.g., hypothyroidism, severe anemia, vitamin B12 deficiency), genetic/degenerative (e.g., CJD, NIID, SCA, WD, PD); 4.Malignancy treatment: current or within the past 2 years, including surgery, radiotherapy, chemotherapy, or immunotherapy; 5.Autoimmune diseases or immunomodulatory therapy: rheumatoid arthritis, systemic lupus erythematosus, post–organ transplantation, or ongoing/past use of corticosteroids or immunosuppressants; 6.Significant data incompleteness or refusal to provide complete study information.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| p-tau 217;IL-6;MOCA score;Glial fibrillary acidic protein; | — |
Countries
China
Contacts
Public ContactWang Guomin
Quangang General Hospital, the First Affiliated Hospital,Fujian Medical University
Outcome results
None listed