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Research on Virtual Reality Co-stimulation Paradigms for Cognitive Function Assessment and Training

Clinical Research Protocol for a Virtual Reality Co-stimulation Paradigm Targeting Cognitive Function Assessment and Training

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500111952
Enrollment
Unknown
Registered
2025-11-07
Start date
2025-11-15
Completion date
Unknown
Last updated
2025-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild cognitive impairment, Subjective cognitive decline

Interventions

MCI Population: Experimental Group:Head-mounted VR rehabilitation training for 20–30 minutes, 5 times per week, for a total of 4 weeks. The HP G2 Reverb Omnicept headset (currently available on the ma
managing cognitive decline risk factors (reducing sedentary time, increasing physical activity and social engagement)
sleep monitoring and adjustment
emotional well-being and coping strategies
and managing underlying conditions like hypertension, diabetes, and hyperlipidemia.
MCI population: control group:All elderly participants in this study will receive standardized care for 4 weeks, 5 times per week, along with phased health education and lifestyle guidance covering: a
managing risk factors for cognitive decline such as reducing sedentary behavior, increasing physical activity and social engagement
addressing emotional well-being and coping strategies
and controlling underlying conditions like hypertension, diabetes, and hyperlipidemia.
SCD population: Experimental group:Head-mounted VR cognitive training for 20–30 minutes, 5 times per week, for a total of 4 weeks. Utilizing the HP G2 Reverb Omnicept headset (currently available on t

Sponsors

School of Nursing, Nanjing University of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
55 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria for MCI population: 1. Age 55-85 years old; 2. Primary school education or above, visual and hearing barrier-free, can cooperate with the completion of the assessment; 3. Overall cognitive function assessment: Mini-Task Mental State Examination Scale (MMSE) >=27 points and =26 points and SCD-Q9>=5 points; 4. Volunteer to participate in this study and sign the informed consent form.

Exclusion criteria

Exclusion criteria: Exclusion Criteria: 1. History of neuropsychiatric diseases, such as cerebrovascular disease, depression, schizophrenia, drug dependence, intracranial tumors, refractory epilepsy, Parkinson's disease, normal pressure hydrocephalus, brain tumors and head trauma surgery, etc.; 2. Diseases of the heart, liver, kidney, hematopoietic system and endocrine system that seriously affect cognitive function; 3. Cranial magnetic resonance has infarct lesions, microbleeds and mass occupancy; 4. Those who are receiving other non-pharmacological interventions.

Design outcomes

Primary

MeasureTime frame
MCI:Cognitive Function ;MCI: Activities of Daily Living (ADL) Scale;MCI: Imaging Acquisition;MCI:Physiological Data Signal Acquisition (EEG data: 5 minutes with eyes closed, 5 minutes with eyes open);MCI:Eye movement data collection (forward saccade reaction time, backward saccade reaction time, backward saccade error rate, eye movement trajectories, etc.);MCI:Functional Near-Infrared Device Evaluation;SCD: Cognitive Function ;SCD: Activities of Daily Living (ADL) Scale;SCD:Imaging Acquisition;SCD:Physiological Data Signal Acquisition (EEG data: 5 minutes with eyes closed, 5 minutes with eyes open);SCD:Eye movement data collection (forward saccade reaction time, backward saccade reaction time, backward saccade error rate, eye movement trajectories, etc.);SCD:Functional Near-Infrared Device Evaluation;

Countries

China

Contacts

Public ContactBai Yamei

School of Nursing, Nanjing University of Chinese Medicine

czbym@njucm.edu.cn+86 195 5199 4118

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026