This study aims to investigate the effect of preoperative administration of esketamine combined with hydrochloride dexmedetomidine nasal spray on the quality of early recovery after endoscopic sinus surgery.
Conditions
Interventions
C:The dexmedetomidine nasal spray group (Group D), the esketamine group (Group E), and the esketamine combined with dexmedetomidine nasal spray group (G
the esketamine group (Group E):The dexmedetomidine nasal spray group (Group D) and the esketamine combined with dexmedetomidine nasal spray group (Group DE)
the dexmedetomidine nasal spray group (Group D):The eszopiclone group (Group E) ? the eszopiclone combined with dexmedetomidine nasal spray group (Group DE)
the eszopiclone combined with dexmedetomidine nasal spray group (Group DE):the dexmedetomidine nasal spray group (Group D) and the esketamine group (Group E)
Sponsors
Shandong Second Provincial General Hospital, Shandong Provincial ENT Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years old; 2. American Society of Anesthesiologists (ASA) classification I-III; 3. Scheduled to undergo endoscopic sinus surgery, with an operation time of 1-3 hours; 4. Planned to receive general anesthesia; 5. All signed informed consent forms and cooperated in data collection.
Exclusion criteria
Exclusion criteria: 1. The operation duration is less than 1 hour or more than 3 hours; 2. Preoperative uncontrolled hypertension (SBP > 180 mmHg) or sinus bradycardia or arrhythmia; 3. Difficult airway assessment; 4. Poor control of hypertension and suffering from severe heart disease; 5. BMI >= 30 kg/m^2; 6. History of chronic pain; 7. Any other reasons that prevent participation in the study, such as patients with mental disorders, etc. 8. Cancer patients;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Self-rating Anxiety Scale score,;Total score of the 40-item Quality of Recovery Scale (QoR-40), and scores of each dimension;Self-rating Depression Scale score; | — |
Countries
China
Contacts
Public ContactZhang Di
Shandong Second Provincial General Hospital, Shandong Provincial ENT Hospital
Outcome results
None listed