Newly diagnosed diabetes
Conditions
Interventions
Patients with diabetes who 'progress to insulin deficiency' and 'progress to severe insulin deficiency':None
Patients who have not progressed to insulin deficiency:None
Sponsors
The Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
14 Years to 40 Years
Inclusion criteria
Inclusion criteria: Target group: new-onset diabetics; 1.Gender is not limited; 2.Age 14-40 years; 3. Diabetes diagnosis =11.1mmol/L (200mg/dL) or Fasting plasma glucose >=7.0mmol/L (126mg/dL) or Plasma glucose at OGTT/2 hours after meal >=11.1mmol/L (200mg/dL) or HbA1c >=6%. 6.5% of HbA1c; (2) If there are no symptoms of diabetes, the test will need to be repeated once on another day to make the diagnosis; 4.Patients with new-onset diabetes mellitus in whom the diagnosis of staging is considered clinically unclear.
Exclusion criteria
Exclusion criteria: 1.Patients who have been clearly diagnosed with T1DM; 2.Gestational diabetes mellitus, monogenic diabetes mellitus (neonatal diabetes mellitus MODY), pancreatic exocrine disease (cystic fibrosis disease), drug or chemical-induced diabetes mellitus; 3.Long-term use of hormones or immunosuppressive drugs treatment; 4.Pregnant or breastfeeding women; 5.The combination of other autoimmune diseases, malignant neoplasms, severe liver and kidney disease, Uremia; 6. Life expectancy of not more than 3 years; 7. Mental illness or other reasons that make it impossible to cooperate with the investigation; 8. Acute stage of diabetic ketoacidosis; 9. Serious infections, fever, trauma, major surgeries, and other stressful situations; 10. Exogenous insulin treatment should be excluded from the IAA test for more than one week; 11. Patients with lack of key clinical information; 12. Patients who are not considered by the researchers to be suitable for participation in the study. The researcher believes that it is not suitable to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Islet autoantibodies: GADA, IA-2A, IAA;T1D GRS Score; | — |
Countries
China
Contacts
Public ContactYang Xiao
The Second Xiangya Hospital of Central South University
Outcome results
None listed