Respiratory tract infection
Conditions
Interventions
Non-exposed group: Healthy volunteers:None
Exposure group: Patients with mild respiratory tract infections:None
Exposure group: Severe patients with respiratory tract infections:None
Sponsors
Liuzhou People’s Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for patients with respiratory tract infections: 1. Age range from 28 days to 80 years old. 2. Patients are clinically diagnosed with respiratory tract infections. The diagnostic criteria are as follows: Infections contracted outside the hospital, including pathogen infections with a clear incubation period. The onset occurred within the incubation period after admission, and possess at least 2 or more of the following clinical features. Clinical symptoms: New onset of cough, expectoration or exacerbation of existing respiratory disease symptoms, fever, shortness of breath, moaning, cyanosis; Signs: Fixed wet rales and/or lung consolidation signs in the lungs; May have wing movement and/or intercostal depression; Chest imaging: New appearance of patchy infiltrates, lobar or segmental consolidation shadows, ground-glass opacities or interstitial changes, with or without pleural effusion. Inclusion criteria for healthy volunteers: 1. Age range: 28 days to 80 years old. 2. No history of chronic diseases such as cardiovascular, liver, kidney, respiratory, hematological, lymphatic, endocrine, immune, mental, neuromuscular, or gastrointestinal systems within the past three years, and overall good health condition. 3. Body Mass Index (BMI) is 18 - 24 kg/m^2. 4. No fever or cough history in the past two weeks, and no use of any antibiotics or antiviral drugs. 5. No vaccination within the past four weeks.
Exclusion criteria
Exclusion criteria: Exclusion criteria for patients with respiratory tract infections: 1. Patients with severe underlying diseases, previous history of tumors, systemic autoimmune diseases, and infectious diseases that can cause opportunistic infections (such as AIDS, syphilis, malaria, histoplasmosis, etc.). 2. Pregnant and lactating women. 3. Patients who have not given informed consent. Exclusion criteria for healthy volunteers: 1. Patients with severe underlying diseases, previous history of tumors, systemic autoimmune diseases, and infectious diseases that can cause opportunistic infections (such as AIDS, syphilis, malaria, histoplasmosis, etc.); 2. Pregnant and lactating women. 3. Patients who have not given informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival and recovery status; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory mediators;Effective treatment rate;Cellomics; | — |
Countries
China
Contacts
Public ContactYing Wu
Liuzhou People’s Hospital
Outcome results
None listed