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Study on the Relationship between Biliary and Intestinal Fluid Microbiota in Patients with Primary choledocholithiasis after Digestive Tract Reconstruction based on Metagenomics and Metabolomics

Study on the Relationship between Bile and Intestinal Flora in Choledocholithiasis after Digestive Tract Reconstruction Surgery Based on Genomics and Metabolomics

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500111930
Enrollment
Unknown
Registered
2025-11-07
Start date
2025-11-10
Completion date
Unknown
Last updated
2025-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bile duct stones

Interventions

Digestive Tract Reconstruction Group:N/A
Non-Digestive Tract Reconstruction Group:N/A

Sponsors

The Second Hospital of Hebei Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (1) Preoperative diagnosis of primary choledocholithiasis (2) No use of antibiotics or probiotic drugs within 3 months (3) No severe infection symptoms or other complicated serious diseases (4) Patients not undergoing emergency ERCP within 12 hours (5) Patients with successful ERCP intubation and bile/intestinal juice collected (6) Patients who have signed the informed consent form

Exclusion criteria

Exclusion criteria: (1) Patients with complicated pancreatitis or biliary malformation (2) Patients who used antibiotics or probiotic drugs preoperatively (3) Patients with bacteremia or septicemia (4) Patients who have not signed the informed consent form

Design outcomes

Primary

MeasureTime frame
Metagenomic next-generation sequencing;Metabonomic analysis;—

Countries

China

Contacts

Public ContactZhang Lichao

The Second Hospital of Hebei Medical University

zhanglichao@hebmu.edu.cn+86 138 3317 1381

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026