Catheter-related bloodstream infections in hemodialysis patients
Conditions
Interventions
Drug-eluting catheter group:According to the requirements of the catheter instruction manual, use the matching tube - sealing solution for the tube - sealing operation.
Ordinary catheter group:After hemodialysis is completed, use conventional catheter sealing solution to seal the catheter.
Sponsors
Huaihai Hospital, Xuzhou Medical University, Xuzhou, Jiangsu, China
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with renal failure aged 18-80 years old; 2. Indwelling central venous catheter; 3. Receiving >=2 hemodialysis sessions per week and having received >=2 sessions prior to enrollment.
Exclusion criteria
Exclusion criteria: 1. Minocycline and rifampicin allergy; 2. Antibiotic therapy <=14 days prior to enrollment; 3. Catheter exit site infection or suspected infection prior to enrollment; 4. Systemic immunosuppression; 5. Extracorporeal circulation intolerance; 6. Patients with malignant tumors with a life expectancy of <=6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to catheter-related infection occurrence;Removal of the catheter for any reason or loss of catheter patency (dialysis blood flow rate <= 100 mL/min); | — |
Secondary
| Measure | Time frame |
|---|---|
| Exclude nausea, vomiting, cough, headache, drowsiness, and other adverse reactions to minocycline and rifampicin caused by other reasons.;CRBSI incidence rate;Medical expenses; | — |
Countries
China
Contacts
Public ContactRen Hongqi
Huaihai Hospital, Xuzhou Medical University
Outcome results
None listed