Pediatric acute hepatic failure
Conditions
Interventions
Observation Group of Children with acute Liver Failure:None
Sponsors
Shenzhen Children’s Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1.For children clinically diagnosed with acute liver failure in children, the PALF diagnostic criteria are acute liver injury in children without evidence of chronic liver disease, manifested as coagulation disorders that cannot be corrected by vitamin K1 supplementation, and one of the following two conditions is met: (1) There are manifestations of hepatic encephalopathy with an international normalized ratio (INR) of coagulation function >=1.5 or prothrombin time (PT)>=15 seconds; (2) When there were no manifestations of hepatic encephalopathy, INR>=2.0 or PT>=20 s(DHAWAN A. lin ResHepatol Gastroenterol,2012). Among them, acute onset hepatolenticular degeneration, autoimmune hepatitis or hepatitis B with unknown infection time are all included in the category of no known chronic liver diseases. With reference to Pediatr Clin N Am 69 (2022) 465-495, acute liver failure was further subdivided into: hyperacute (within 1 week), acute (8-28 days), and subacute (4-12 weeks) based on the interval between jaundice episodes and the development of coagulation dysfunction and/or encephalopathy. 2. Gender is not limited. 3. Age range: 0 to 18 years old; 4. Those who agree to participate in this project and have signed a written informed consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria (meeting any of the following criteria) : 1. Combined with diabetes and hyperthyroidism; 2. Combined with severe heart, brain, kidney diseases and other systemic diseases; 3. Combined with malignant tumors; 4. Chronic liver failure; 5. Poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biomolecules (including BCAT2) used for disease detection in exosome contents;evDNA;Outcomes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Glutamic oxaloacetic transaminase;Ammonia;Prothrombin time;PT international standardization ratio;Prothrombin activity;Total bilirubin;Direct bilirubin;Serum albumin;Lactic acid;Serum sodium;Creatinine;Liver ultrasonic findings;Glutamic-pyruvic transaminase; | — |
Countries
China
Contacts
Public ContactDongling Dai
Shenzhen Children’s Hospital
Outcome results
None listed