Acute type A aortic dissection
Conditions
Interventions
RIPC Intervention Group:Participants randomized to this group will receive remote ischemic preconditioning (RIPC) treatment. After induction of general anesthesia and thoracotomy, RIPC is applied to t
Sham Control Group:Participants randomized to this group will receive a sham RIPC procedure. The same cuff placement and timing as the experimental group are used, but the cuff is inflated to only 20
Sponsors
Fujian Medical University Union Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Age between 18 and 70 years, regardless of gender. (2) Diagnosis of acute type A aortic dissection requiring emergency surgery (Time from symptom onset to surgery is less than 14 days). (3) Ability to understand the purpose of the trial, voluntary participation, provision of signed informed consent, and willingness to accept follow-up.
Exclusion criteria
Exclusion criteria: (1) Traumatic or iatrogenic aortic dissection. (2) Severe pre-operative organ dysfunction: Patients with persistent deep coma, Patients with abdominal compartment syndrome, Patients with circulatory failure. (3) Severe comorbidities: History of myocardial infarction within 1 month, History of stroke within 3 months, End-stage renal disease. (4) Presence of peripheral arterial disease involving the limbs, Raynaud's syndrome, active phlebitis, severe deformity in the limb intended for RIPC application, history of arterial surgery in the intended limb, or inability to palpate arterial pulses in the intended limb. (5) Current use of sulfonylurea oral hypoglycemic drugs or nicorandil medication. (6) Expected survival time of less than one year (e.g., advanced malignant tumor). (7) Participation in other clinical trials where the primary endpoint has not been reached. (8) Patients who were pregnant, immunocompromised (including HIV-positive status, history of organ transplantation, etc.), had known bleeding disorders or coagulopathy, or had active/uncontrolled infection. (9) Patients with other severe physical or mental illnesses, or abnormal laboratory findings that may increase the risk of participation, interfere with the results, or who were deemed by the investigator as unsuitable for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean Daily SOFA-2 Score during Postoperative ICU Stay; | — |
Secondary
| Measure | Time frame |
|---|---|
| Maximum SOFA-2 Score in First 3 Postoperative Days;RIPC Technical Success Rate;Operative Time;Cardiopulmonary Bypass Time;Aortic Cross-Clamp Time;Circulatory Arrest Time;Duration of Mechanical Ventilation;ICU Length of Stay;Hospital Length of Stay;30-Day All-Cause Mortality;Incidence of Major Postoperative Complications;1-Year All-Cause Mortality;1-Year Aortic Re-intervention Rate; | — |
Countries
China
Contacts
Public ContactLiang-wan Chen
Fujian Medical University Union hospital
Outcome results
None listed