The mechanism of action of Remimazolam Tosilate
Conditions
Interventions
18 to 44 years old:From the induction of anesthesia to the maintenance during the operation, total intravenous anesthesia was implemented based on the induction dose of 0.3mg/kg and the maintenance do
Narcotrend reference value D level), the actual induction and maintenance doses were adjusted appropriately to control the appropriate anesthesia depth.
45 to 64 years old:From the induction of anesthesia to the maintenance during the operation, total intravenous anesthesia was implemented based on the induction dose of 0.3mg/kg and the maintenance do
65 to 79 years old:From the induction of anesthesia to the maintenance during the operation, total intravenous anesthesia was implemented based on the induction dose of 0.15mg/kg and the maintenance d
80 years old and above:From the induction of anesthesia to the maintenance during the operation, total intravenous anesthesia was implemented based on the induction dose of 0.15mg/kg and the maintenan
Sponsors
Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong Science and Technology University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Age over 18 years old; (2) ASA grade I-II of the American Society of Anesthesiologists; (3) Patients scheduled for general anesthesia (intravenous anesthesia) for tracheal intubation or laryngeal mask insertion surgery; (4) Patients requiring arterial puncture for surgery; (5) Informed consent, voluntary participation in this trial, and signing of the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients with cardiac function grade 3 or above; (2) Patients undergoing head and neck surgeries where it is difficult to observe the size of the pupils; (3) Patients undergoing multi-modal anesthesia methods such as combined nerve block and spinal anesthesia; (4) Patients known to be allergic to tropisetron hydrochloride or benzodiazepine drugs; (5) Surgical types and categories where the surgical operation directly affects hemodynamics, such as major vascular surgeries; (6) Patients with abnormal coagulation function, endocrine diseases or other conditions that affect the hemodynamic state; (7) Short surgeries (surgery duration < 1 hour); (8) Surgeries with a duration of more than 4 hours; (9) Patients with neurological diseases that affect cognition; (10) Patients with a history of drug and alcohol dependence; (11) Patients that the researchers consider not suitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The dosage of Remimazolam tosilate for anesthesia induction and maintenance;The levels of remimazolam tosilate and its metabolites in blood samples;The expression levels of GABA receptor subunits in blood samples;Postoperative levels of inflammatory factors (such as IL-6, TNF-a); | — |
Secondary
| Measure | Time frame |
|---|---|
| Anesthesia induction time;Anesthesia recovery time;MMSE in PACU;VAS in PACU;LOS: length of hospital stay;Postoperative mortality rate at 30 day; | — |
Countries
China
Contacts
Public ContactQiaoqiao Xu
Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong Science and Technology University
Outcome results
None listed