Autism Spectrum Disorder
Conditions
Interventions
Experimental group:Intravenous Immunoglobulin
Sponsors
The First Medical Center of PLA General Hospital
Eligibility
Sex/Gender
All
Age
3 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1. Conform to The Diagnostic criteria for ASD in the Diagnostic and Statistical Manual of Mental Disorders- Fifth Edition (DSM-V); 2. Age: 3 to 12 years old, gender not limited. 3. After ruling out active inflammation in other parts, the serum cytokine test shows that any one of the cytokines IL-1, IL-2, IL-6, IL-8, IL-10 or TNF-a is more than 1.5 times higher than the upper limit of normal. 4. No known immune deficiency diseases, and no major functional abnormalities in blood routine, liver, kidney, heart or lung. 5. Clinical research participants and/or guardians can fully understand the informed consent content of this study and voluntarily sign the informed consent form; 6. Improve the preoperative eight items of serum and humoral immunity tests, and rule out contraindications for hepatitis C.
Exclusion criteria
Exclusion criteria: 1. The patient has a history of tumors or tumors (including hematological tumors and solid tumors); 2. There is a history of severe allergic reactions and blood product allergies in the past; 3. Autism caused by clear single-gene diseases, chromosomal abnormalities, or abnormal brain development; 4. Accompanied by other mental disorders besides autism spectrum disorder; 5. Participated in other clinical studies or experimental treatments related to ASD in the past half year; 6. Situations where other researchers consider it inappropriate to be included in the group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SRS score results;Results of ABC scores on the Vineland scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse events during treatment;The changes in serum inflammatory factor levels after treatment;The changes in serum metabolomics indicators after treatment; | — |
Countries
China
Contacts
Public ContactGuang Yang
The First Medical Center of PLA General Hospital
Outcome results
None listed