Obesity
Conditions
Interventions
Obesity placebo:Same volume of pure water (placebo, 300 mL, to be consumed within 2 minutes)
Control placebo:Same volume of pure water (placebo, 300 mL, to be consumed within 2 minutes)
Obesity fructose:A single dose of high-fructose beverage (fructose solution, dose 0.75 g/kg, 300 mL, consumed within 2 minutes).
Control fructose:A single dose of high-fructose beverage (fructose solution, dose 0.75 g/kg, 300 mL, consumed within 2 minutes).
Sponsors
Shanghai Fengxian District Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Healthy Participants: 1.Age: 18–45 years; both genders eligible, able to comprehend and sign the informed consent form. 2.Body Mass Index (BMI): 18.5–24 kg/m^2. 3.No prior history of diabetes, severe cardiovascular, hepatic/renal diseases, or mental disorders. Obese Participants: 1.Age: 18–45 years; both genders eligible; able to understand the study protocol and voluntarily sign the informed consent form. 2.Body Mass Index (BMI): >=28.0 kg/m^2[12]. Metabolic Status: 3.May have simple obesity or metabolic abnormalities (e.g., fasting blood glucose 6.1–7.0 mmol/L or postprandial 2-hour glucose 7.8–11.1 mmol/L, but not meeting diabetes diagnostic criteria). 4.Health Status: No prior history of diabetes, severe cardiovascular, hepatic/renal diseases, or mental disorders.
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1.History of alcohol addiction or recent heavy drinking; pregnant or breastfeeding women; 2.Allergy or intolerance to the trial beverage components; 3.Recent use (within 3 months) of antibiotics, probiotics, or other treatments altering gut microbiota; 4.Any other circumstances deemed unsuitable by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood metabolic indicators (glucose, insulin, triglycerides, uric acid, liver function, etc.); | — |
Countries
China
Contacts
Public ContactZhang Shan
Shanghai Fengxian District Central Hospital
Outcome results
None listed