Primary patients confirmed by histopathology to have high-grade serous epithelial ovarian cancer (HGSOC)
Conditions
Interventions
Observation group:None
Sponsors
The First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Pathological diagnosis: Primary patients confirmed by histopathology to have high-grade serous epithelial ovarian cancer (HGSOC); 2.Specimen source: The specimens were obtained from surgical or biopsy samples at the First Affiliated Hospital of Wenzhou Medical University; 3.Clinical data: The patient has complete clinical and pathological information (including age, FIGO staging, chemotherapy regimen, imaging, and follow-up data, etc.); 4. Specimen Quality: Formalin-fixed, paraffin-embedded (FFPE) tissue specimens are well-preserved and suitable for pathological staining analysis.
Exclusion criteria
Exclusion criteria: 1.Non-high-grade serous ovarian carcinoma subtypes (such as mucinous, endometrioid carcinoma, etc.); 2.Metastatic ovarian cancer or cases where the primary site is unclear; 3.Has received neoadjuvant chemotherapy or targeted therapy; 4.Poor specimen quality (e.g., insufficient tissue, improper fixation, or severe degradation); 5. Cases with missing clinical or pathological data, or incomplete follow-up information.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ovarian cancer tumor markers and the expression levels of specific targets (such as MSLN);CAR transduction efficiency;T cell subset; | — |
Secondary
| Measure | Time frame |
|---|---|
| Objective response rate, ORR;Disease control rate, DCR; | — |
Countries
China
Contacts
Public ContactOu Rongying
The First Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed