Depression, anxiety, insomnia, loss of pleasure, etc
Conditions
Interventions
Experimental group:Graphene far-infrared intervention
Sponsors
The Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Age: 18 - 65 years old, right-handed; 2. Meets the diagnostic criteria for depression as stipulated in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5); 3.Total score of HAMD-24 >= 20 points; 4.According to the Mosley Staging Method (MSM), there is moderate to severe treatment resistance, with a score higher than 6 points; 5.Physical examination, medical history, vital signs, routine blood, urine and stool tests, liver and kidney function, electrolytes, electrocardiogram, and electroencephalogram of the patient are all normal; 6.After fully understanding the safety of graphene far-infrared, the patient is willing to cooperate with the treatment and signs an informed consent form with both the patient and the family members; 7.All patients are taking selective serotonin reuptake inhibitors (SSRI) drugs.
Exclusion criteria
Exclusion criteria: 1.History of severe physical diseases and depression caused by psychoactive substances and non-addictive substances; 2.Patients with implanted metal or electronic devices, such as intracranial metal foreign bodies, cochlear implants, cardiac pacemakers, and metal foreign bodies in the heart, etc.; 3. At risk of epileptic seizures, with previous cranial diseases, head trauma, alcohol abuse, abnormal electroencephalograms, MRI evidence of brain structural abnormalities, or a family history of epilepsy; 4.With psychotic symptoms requiring combined use of antipsychotic drugs; 5.Received ECT or other physical therapy within 3 months prior to enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale (HAMD-24) Score;Hamilton Anxiety Scale (HAMA) Score;Montreal-Asberg Depression Scale (MADRS) Score;Pittsburgh Sleep Quality Index (PSQI);Snays-Hamilton Pleasure Scale (SHAPS) Score;Chinese Version of Beck Suicide Ideation Scale (BSI-CV) Score;Neuropsychological Status Assessment Scale (RBANS) Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Brain region activation, functional connectivity, plasticity changes, etc; | — |
Countries
China
Contacts
Public ContactDongsheng Zhou
The Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed