Acute ischemic stroke
Conditions
Interventions
Standard medication group:None
EVT combined with standard medical therapy group:None
Sponsors
The Second Affiliated Hospital of the Army Medical University PLA
Eligibility
Sex/Gender
All
Age
18 Years to 120 Years
Inclusion criteria
Inclusion criteria: 1.Patients with acute anterior circulation occlusion or posterior circulation occlusion (intracranial segment of internal carotid artery, M1-M3 segment of middle cerebral artery, A1-A3 segment of anterior cerebral artery, V4 segment of vertebral artery, P1-P3 segment of basilar artery and posterior cerebral artery); 2.Preoperative mild or above dysfunction (MRS>= 2) lasting for at least 3 months; 3.Written informed consent signed by patients or family members; 4.18 <= age <= 120.
Exclusion criteria
Exclusion criteria: 1.Pregnant or lactating women; 2.The symptoms and signs were aggravated after the first stroke, and the diagnosis was progressive stroke; 3.Intracranial hemorrhage confirmed by computed tomography (CT) or magnetic resonance imaging (MRI); 4.Researchers judged that the duration of disability before stroke was too short; 5.Expected failure to complete follow-up; 6.Midline displacement of brain due to cerebral hernia; 7.Other clinical trials currently involved will affect the results of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SICH within 48h;Proportion of patients with functional recovery at 90 days (i.e., 90-day mRS score not increased compared to pre-stroke mRS score);90 day mortality;Any intracranial hemorrhage within 48h;;Score distribution with Mrs score of 0-3, 4, 5 or 6 at 90 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| The change in modified Rankin Scale (?mRS) from baseline to 90 days (ranging from -2, -1, 0, 1, 2, 3, 4, 5, 6 on the ordinal scale).;Changes in NIHSS scores at 5-7 days or early discharge;Recanalization rate ((mtici = 2b);Percentage of patients with 90-day mRS score of 0-2;Expanded (eTICI) scores (only in EVT group);Percentage of patients with 90-day mRS score of 0-3;Percentage of patients with 90-day mRS score of 0-1;Distribution of 90-day mRS scores; | — |
Countries
China
Contacts
Public ContactWenjie Zi
The Second Affiliated Hospital of the Army Medical University PLA
Outcome results
None listed