Chronic pain
Conditions
Interventions
Group C:Duloxetine 20mg po tid+ 250ml normal saline intravenous drip for 5 days.
Group EK-1:Esketamine 0.2mg/kg is added to 250ml of normal saline for intravenous drip for 1 day + 250ml of normal saline for intravenous drip for 4 days.
Group EK-2:Esketamine 0.2mg/kg is intravenously infused into 250ml of normal saline for 5 days.
Sponsors
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. The pain persists or recurs for more than three months; 2. Patients with moderate or severe depression (BDI score > 15 points); 3. NRS score>=5 points; 4. Age >=18 years old, gender not limited; 5.Have good comprehension ability and be capable of understanding the treatment plan and follow-up;6. Voluntary and signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those with severe dysfunction of organs such as the heart, lungs, liver and kidneys; 2. Those with a history of mental illness; 3. Patients who are allergic to Esketamine Hydrochloride injection or have contraindications; 4. During pregnancy or lactation; 5. Unable to cooperate normally to complete the questionnaire and follow-up visits.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| General signs;Beck Depression Scale (BDI, Self-Rating Scale); | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety indicators;NRS score;Satisfaction Rating;Short-Form McGill Pain Questionnaire-2 (SF-MPQ-2); | — |
Countries
China
Contacts
Public ContactLin Xiaowen
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Outcome results
None listed