Sepsis-induced coagulopathy
Conditions
Interventions
Xuebijing Treatment Group:TheXuebijing Treatment group received 100ml of XBJ + 100ml of normal saline for 12 consecutive hours, followed by standard treatment with SIC for 5 days.
Control treatment group:The control group received 100ml of placebo + 100ml of normal saline for 12 hours, and was treated with standard SIC for 5 consecutive days.
Sponsors
Shanghai East Hospital (East Hospital Affiliated to Tongji University)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18-80 years old, meeting Sepsis-3 diagnostic criteria (infection +?SOFA or ?qSOFA>=2 points). 2.SIC score >=4 points (based on ISTH 2017 standard) (for details, see Appendix 2). 3.The time from Sepsis to the diagnosis of SIC is less than or equal to 24 hours. 4. No anticoagulant and antiplate therapy was received before diagnosis.
Exclusion criteria
Exclusion criteria: 1.There are other coagulation disorders (TTP, HIT, hemolytic uremic syndrome). 2. There are serious primary diseases, including tumors discovered within half a year, hematological diseases, and severe liver and kidney diseases (such as liver cirrhosis and terminal chronic renal failure). 3. Pregnant or lactating women. 4.Within 4.6 months, immunosuppressants have been used or organ transplants have been received. 5. Has participated in other clinical trials. 6. Patients who the researchers considered unsuitable to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SIC remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Coagulation index;Inflammatory indicators;APACHE?score;SOFA score;28-day all-cause mortality rate;Mechanical ventilation time;Blood purification time;Four items of new thrombosis;Cellular immune function; | — |
Countries
China
Contacts
Public ContactFeng Zhu
Shanghai East Hospital (East Hospital Affiliated to Tongji University)
Outcome results
None listed