Early Allograft Dysfunction after Liver Transplantation
Conditions
Interventions
Pathological Hyperlactatemia Group:None
Physiological Hyperlactatemia Group:None
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18 - 70 years who underwent allogeneic liver transplantation; 2. Intraoperative lactate levels were monitored (including data at least at three time points: at the time of skin incision, 30 minutes after portal vein reperfusion, and at the end of surgery) 3. Postoperative follow - up time >= 7 days, with complete evaluation indicators for early allograft dysfunction (EAD) (such as bilirubin, INR, ALT/AST, etc. from 1 to 7 days after surgery) 4. Informed consent was signed by the patient or their authorized family members (for retrospective studies, the conditions for waiver of informed consent in line with ethical requirements must be met
Exclusion criteria
Exclusion criteria: 1. Preoperative presence of severe lactic acid metabolism disorders (such as congenital lactic acidosis, mitochondrial diseases); 2. Preoperative presence of severe lactic acid metabolism disorders (such as congenital lactic acidosis, mitochondrial diseases);? Concurrent combined transplantation of other organs during liver transplantation (such as liver - kidney combined transplantation); 3. Death during surgery or within 24 hours after surgery; 4. Incomplete clinical data or samples; 5. Preoperative presence of severe infections or autoimmune diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Early Allograft Dysfunction after Liver Transplantation;Lactic acid;Liver Function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Complete Blood Count;Renal Function;Postoperative Complication;ICU Length of Stay;Inflammatory Factor;Lactylation;Ferroptosis;30-Day Postoperative Mortality; | — |
Countries
China
Contacts
Public ContactXiaolian Nong
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed