None
Conditions
Interventions
Bupivacaine liposome group (L group):General anesthesia combined with anterior deltoid plane block anesthesia was adopted. The local anesthetic used was bupivacaine liposome.
Bupivacaine group (Group B):General anesthesia combined with anterior deltoid plane block anesthesia was adopted. The local anesthetic was bupivacaine.
Sponsors
Zhongshan Hospital(Xiamen), Fudan University
Eligibility
Sex/Gender
Female
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 to 85 years old 2. Patients undergoing elective modified radical mastectomy for breast cancer 3. Body Mass Index (BMI) between 18 and 32 4. Female gender 5. Subjects voluntarily participating in this clinical study
Exclusion criteria
Exclusion criteria: 1. Hepatic insufficiency 2. Renal insufficiency 3. Central nervous system disorders, psychiatric conditions 4. Infection near the puncture site 5. Coagulation disorders 6. Uncooperative or non-communicative patients 7. History of chronic pain, chronic alcohol consumption, or substance abuse 8. Pregnant women 9. Patients refusing analgesic pumps or presenting with preoperative psychological conditions such as anxiety or depression 10. Patients with allergies to the investigational medicinal product
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative 24-hour recovery quality;The time of the patient's first use of the analgesic pump; | — |
Secondary
| Measure | Time frame |
|---|---|
| The cumulative consumption of opioid drugs within 72 hours after the operation;Postoperative resting and active NRS scores;The recovery quality of the patient 48 hours and 72 hours after the operation;The incidence of postoperative nausea and vomiting;Overall benefit of patient pain relief score (OBAS);The patient's sleep quality on the night of the surgery;The occurrence rate of anesthesia-related complications after surgery;The time when the patient first got out of bed to move around;Total length of hospital stay;surgical complications;The occurrence of chronic postoperative pain; | — |
Countries
China
Contacts
Public ContactZhiyao Wang
Zhongshan Hospital, Fudan University; Zhongshan Hospital(Xiamen), Fudan University
Outcome results
None listed